Connecticut is making strides in legalizing cannabis (so to speak): Weekly Review

By now, many in the industry are aware of the recent trend around delta-8-tetrahydrocannabinol (THC), a natural component of cannabis that has become increasingly popular in recent months.

And it seems once the industry gets a solid understanding of Delta-8, another THC compound has come into the spotlight: Delta-10 THC.

Similar to Delta-8, Delta-10 is a minor cannabinoid found in trace amounts in hemp and cannabis, according to the ACS Laboratory, a cannabis, hemp, and cannabidiol (CBD) testing laboratory in Florida.

As previously reported by Hemp Grower, Delta-8 is said to have a relaxing effect and induce some psychotropic effects that are believed to be less potent than Delta-9.

Roger Brown, the president and founder of ACS Laboratory, describes the effects of Delta-10 as the opposite of Delta-8 based on personal experience.

“For myself, I don’t use or smoke marijuana, but I’ve tried Delta-8 and Delta-10 products that we tested as an experiment, and for me, Delta-10 had no psychoactive effects; it was more of a mood enhancer, ” he says.

Erik Paulson, senior analyst at Infinite Chemical Analysis Labs, an analytical cannabis and CBD testing laboratory with locations in California and Michigan, says consumers have compared the effects of Delta-10 to sativa cannabis strains traditionally known to be energizing and uplifting, and delta-8 effects on indica strains associated with relaxation.

However, Paulson says he’s not sure if there is any scientific evidence for this, adding, “It could simply be that the higher psychoactivity of Delta-8 compared to Delta-10 has a stronger sedative effect.”

At this point, Paulson and Brown both say that there is some published research on Delta-10, although it is minimal.

A pigeon study conducted in the 1980s by Raphael Mechoulam, a pioneer in cannabis research, looked at the effects of Delta-10 compared to Delta-9 on pigeons. The study found that Delta-10 can have some psychoactive effects, but the effects are much less potent than Delta-9.

“Not that much is known about Delta-10 when it comes to psychoactivity and how it affects the human body,” says Paulson.

Where does it come from

Like Delta-8, Delta-10 can be converted from Delta-9 or CBD in a lab, Paulson says.

Delta-10 is typically made predominantly by extraction or converted from Delta-9 by isomerization, he says. Converting Delta-9 to Delta-10 (or Delta-8) is possible because they have the same chemical compounds, just different structures.

According to Extraction Magazine, extractors would waste a lot of time and plant material trying to extract Delta-10 from natural strains so it’s more likely to be made through isomerization. Delta-10 occurs in such low quantities that laboratories often misidentify the compound [cannabichromene] CBC or [cannabicyclol] CBL using standard high performance liquid chromatography (HPLC) methods.

“You can create any Delta you want – Delta-8, Delta-9, or Delta-10 – by chemically altering CBD isolate or CBD crude oil,” said David Reckles, president of Private Label Hemp Lab, a hemp testing and manufacturing laboratory in Florida, said ACS lab. “When you use raw CBD, you generally create the reaction through carbon and vitamin C derivatives. If you use an isolate, you will incorporate solvents and acids. “

RELATED: Understanding Delta-8 THC: Where Does It Come From?

Delta-10 vs. Delta-8 and Delta-9: Chemical differences

Delta-10 is an isomer of Delta-9, says Brown.

Paulson says when you start isolating Delta-9, or, more commonly, converting THC to CBD, you will start discovering the additional isomers (or different classifications of THC).

“Actually, all THC isomers have the same basic chemical structure,” he says. “It’s just the placement of a bond that differs between the different isomers.”

For example, as previously reported by Hemp Grower, “Delta-8 has a double bond on the 8th carbon chain and Delta-9 has a double bond on the 9th carbon chain.”

Delta-10 follows the same pattern and has a double bond on the 10th carbon chain. And although this looks like a “small difference”, it is enough to produce slightly different cognitive and physical effects, “hemp growers reported earlier.

Brown says one significant difference is that Delta-8 can essentially only produce one compound, while Delta-10 can produce up to six different isomers (variations of the same compound).

“What we call Delta-10 is actually a mixture of two different types of connections that may have different configurations,” says Paulson. “So there are so many different compounds, and that’s one of the reasons it’s so difficult to quantify precisely. So when it comes to psychoactivity, you don’t have to test one compound, you have to test six.”

Legal status

According to ACS Laboratory, “Delta-10-THC, which is derived from cannabis,” [federally] illegal because marijuana is a Schedule 1 controlled substance. However, Delta-10 from hemp extract is in a legal gray area. “

And Brown agrees, arguing that the Agriculture Improvement Act of 2018 (the 2018 Farm Bill) is very “Delta-9 specific” and when a hemp-derived Delta-8 or Delta-10 product is less than 0.3 If it contains% total THC (defined as Delta-9-THC plus tetrahydrocannabinolic acid (THCA), its acidic version), it is considered “legal”.

The response of the Drug Enforcement Administration (DEA) to the Farm Bill 2018 is: “All synthetically obtained tetrahydrocannabinols remain controlled substances according to Schedule 1.”

“In our opinion, all tetrahydrocannabinole cannabinoids are federally illegal,” says Paulson. “We don’t judge whether it’s right or not. I just think there haven’t been many legal challenges to these laws and up to that point people keep making Delta-8 and Delta-10 products … “

More than 12 states have already started implementing Delta-8 bans, while very few states, including New York, Colorado and Alabama, have started cracking down on Delta-10.

And Paulson says while Delta-10 may be “under the radar” right now, he thinks it is only a “matter of time” before heightened regulation is in place.

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